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SFB 902

During the funding period 2011-2015, we have been members of the Collaborative Research Center CRC/SFB 902 ("Molecular Principles of RNA-Based Regulation") that addresses the relationship between the structural versatility and conformational dynamics of RNA and its biological functions on a fundamental level.

Within this CRC/SFB, we employ molecular dynamics and quantum-classical approaches to explore the interaction between RNA and small ligand species like photoswitches that act in a regulatory fashion.

Recent publications include:

In search of an efficient photoswitch for functional RNA: Design principles from a microscopic analysis of azobenzene-linker-RNA dynamics with different linkers
P. Mondal, M. Biswas, T. Goldau, A. Heckel, I. Burghardt
J. Phys. Chem. B, 119, 11275 (2015)
doi: 10.1021/acs.jpcb.5b03118

Reversible photoswitching of RNA hybridization at room temperature with an azobenzene C-nucleoside
T. Goldau, K. Murayama, C. Brieke, S. Steinwand, P. Mondal, M. Biswas, I. Burghardt, J. Wachtveitl, H. Asanuma, A. Heckel, Chem. Eur. J., Chem. Eur. J. 21, 2845 (2015)
doi: 10.1002/chem.201405840

Azobenzene photoisomerization induced destabilization of B-DNA
M. Biswas, I. Burghardt, Biophys. J., 107, 932 (2014)
doi: 10.1016/j.bpj.2014.06.044

Molecular dynamics study of the controlled destabilization of an RNA hairpin structure by a covalently attached azobenzene switch, D. Rastaedter, M. Biswas, I. Burghardt, J. Phys. Chem. B, 118, 8478 (2014)
doi: 10.1021/jp501399k

Ultrafast C-spiro-O dissociation via a conical intersection drives spiropyran to merocyanine photoswitching
S. Prager, I. Burghardt, A. Dreuw, J. Phys. Chem. A, 118, 1339 (2014)
doi: 10.1021/jp4088942

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